Department of Microbiology & Molecular Genetics Click here for the Department of Microbiology & Molecular Genetics Home Page Click here for the UC Irvine Home Page Click here for the School of Medicine Home Page
 
 
 
 
bison gate

EMPLOYMENT

Postdoctoral Position – Microbial Pathogenesis

A post-doctoral scholar position funded by NIH and the American Cancer Society (Ph.D. required) is available to study Chlamydia, the most commonly reported cause of infectious disease in the U.S. Ongoing projects are focused on 1) Gene regulation: how chlamydial genes are temporally regulated during the unusual developmental cycle; and 2) Host-pathogen interactions (collaboration with Dr. Christine Sütterlin, Dept. of Developmental and Cell Biology, UC Irvine): how this intracellular bacterium alters the centrosome, cell cycle and membrane trafficking in its infected host cell. Experience in transcriptional regulation, protein purification, cellular microbiology, cell biology, or microscopy would be advantageous. To apply, send a CV, contact information for three references, and a brief description of your research interests to: Dr. Ming Tan, Dept. of Microbiology and Molecular Genetics, B240 Med Sci, University of California, Irvine, CA 92697-4025, or email: mingt@uci.edu. The University of California, Irvine is an equal opportunity employer committed to excellence through diversity.

Position: Specialists, Open Ranks

Junior, Assistant, Associate and full Specialist positions are periodically available in the Department of Microbiology and Molecular Genetics at the University of California, Irvine

Requirements – Applications are being sought from B.S., M.S., or Ph.D. degreed candidates with strong laboratory research background and knowledge of a wide set of molecular biology techniques.  Salary is commensurate with experience.

Faculty and their research interests:

  • Alan G. Barbour

Molecular pathogenesis and evolutionary biology of vector-borne infections

  • Emiliana Borrelli

The study of the dopaminergic system is approached through the generation and analysis of genetically engineered mice (knock-out mice) in which expression of dopamine receptors has been altered or abolished. The analysis of these mice at the molecular, biochemical and behavioral levels allows us to study the implication of dopamine receptors’ signaling in the control of dopamine-regulated physiological functions which range from motor control to addiction to drugs of abuse. These studies are relevant to the understanding of human neurological and neuropsychiatric disorders.

  • Alan L. Goldin

Molecular and cell biology of sodium channels and diseases caused by sodium channel mutations

  • Klemens J. Hertel

Alternative splicing in biology and disease; quantitative and computational approaches to gain insights into the most critical steps of generating mRNA diversity, splice-site selection and pairing

  • Anthony A. James

Developing genetic techniques to control the transmission of vector-borne diseases, specifically malaria and dengue fever; investigating genome-wide patterns of gene expression in vector mosquitoes.

  • Michael McClelland
Genetics and genomics of Salmonella, with a particular emphasis on high-throughput methods, bioinformatics and statistics. The use of Salmonella as a delivery agent for cancer therapeutics. Prostate cancer diagnosis and prognosis.
  • Manuela Raffatellu

Mechanisms of Salmonella interaction with the intestinal mucosa; mucosal barrier function during Salmonella infection.

  • Rozanne M. Sandri-Goldin

Analyses of the mechanisms by which a herpes virus regulatory protein mediates inhibition of host cell splicing and facilitates the export of viral RNAs

  • Bert L. Semler

RNA virus gene expression; mechanisms of replication of picornavirus genomic RNAs; mechanisms of translation initiation for viral and cellular mRNAs

  • Yongsheng Shi

Mechanisms and regulation of mRNA processing, including splicing and polyadenylation, on a systems level; molecular basis of human diseases that are caused by aberrant mRNA processing

  • Eric J. Stanbridge

Molecular genetic analysis of oncogenes and tumor suppressor genes in human cancer

  • Ming Tan

Molecular pathogenesis of Chlamydia (cause of sexually transmitted disease and linked with heart disease); transcriptional regulation of gene expression; studying global gene expression using DNA microarrays

  • Marian L. Waterman

Role of LEF/TCF proteins in Wnt signaling and cancer: expression, transcription activation and nuclear localization

Position: Postdoctoral Scholars

Postdoctoral positions for recent PhD. graduates are periodically available in the Department of Microbiology and Molecular Genetics at the University of   California, Irvine. Salary is commensurate with experience.

Requirements – Applications are being sought from recent Ph.D graduates.  Salary is commensurate with experience.

Faculty and their research interests:

  • Alan G. Barbour

Molecular pathogenesis and evolutionary biology of vector-borne infections

  • Emiliana Borrelli

The study of the dopaminergic system is approached through the generation and analysis of genetically engineered mice (knock-out mice) in which expression of dopamine receptors has been altered or abolished. The analysis of these mice at the molecular, biochemical and behavioral levels allows us to study the implication of dopamine receptors’ signaling in the control of dopamine-regulated physiological functions which range from motor control to addiction to drugs of abuse. These studies are relevant to the understanding of human neurological and neuropsychiatric disorders.

  • Alan L. Goldin

Molecular and cell biology of sodium channels and diseases caused by sodium channel mutations

  • Klemens J. Hertel

Alternative splicing in biology and disease; quantitative and computational approaches to gain insights into the most critical steps of generating mRNA diversity, splice-site selection and pairing

  • Anthony A. James

Developing genetic techniques to control the transmission of vector-borne diseases, specifically malaria and dengue fever; investigating genome-wide patterns of gene expression in vector mosquitoes

  • Michael McClelland
Genetics and genomics of Salmonella, with a particular emphasis on high-throughput methods, bioinformatics and statistics. The use ofSalmonella as a delivery agent for cancer therapeutics. Prostate cancer diagnosis and prognosis.
  • Manuela Raffatellu

Mechanisms of Salmonella interaction with the intestinal mucosa; mucosal barrier function during Salmonella infection

  • Rozanne M. Sandri-Goldin

Analyses of the mechanisms by which a herpes virus regulatory protein mediates inhibition of host cell splicing and facilitates the export of viral RNAs

  • Bert L. Semler

RNA virus gene expression; mechanisms of replication of picornavirus genomic RNAs; mechanisms of translation initiation for viral and cellular mRNAs

  • Yongsheng Shi

Mechanisms and regulation of mRNA processing, including splicing and polyadenylation, on a systems level; molecular basis of human diseases that are caused by aberrant mRNA processing

  • Eric J. Stanbridge

Molecular genetic analysis of oncogenes and tumor suppressor genes in human cancer

  • Ming Tan

Molecular pathogenesis of Chlamydia (cause of sexually transmitted disease and linked with heart disease); transcriptional regulation of gene expression; studying global gene expression using DNA microarrays

  • Marian L. Waterman

Role of LEF/TCF proteins in Wnt signaling and cancer: expression, transcription activation & nuclear localization

Application Procedure - Please send curriculum vitae with names and address of three references (email preferred) to:

Personnel Analyst
Department of Microbiology and Molecular Genetics
School of Medicine
University of California, Irvine
Irvine, Ca 92697-4025
Email: mmg2008@uci.edu          

http://www.microbiology.uci.edu/

The University of California, Irvine is an equal opportunity employer committed to excellence through diversity.